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Benzocaine Raw Steroid Powders for Local Anesthetic CAS 94-09-7

Benzocaine Raw Steroid Powders for Local Anesthetic CAS 94-09-7

Categories Raw Steroid Powders
Brand Name: ChineseHormone
Model Number: CAS 94-09-7
Certification: GMP, ISO 9001, USP
Place of Origin: China
MOQ: Free samples Available
Price: negotiated
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000 kg / month
Delivery Time: 3-7 working days
Packaging Details: as your required
melting point: 92 °C
Water Solubility: 1310 mg/L (at 30 °C)
Appearance: White crystalline powder
boiling point: 310 °C
usage: local anesthetic
Shipment:: FedEx, TNT, EMS, DHL.UPS,EUB
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Benzocaine Raw Steroid Powders for Local Anesthetic CAS 94-09-7


Benzocaine Raw Steroid Powders for Local Anesthetic CAS 94-09-7


Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax.


Chemical properties


Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform and ethyl ether. The melting point of benzocaine is 88–90 °C, and the boiling point is about 310 °C.The density of benzocaine is 1.17 g/cm3.


History


Benzocaine was first synthesized in 1890 by the German chemist Eduard Ritsert (1859–1946),in the town of Eberbach and introduced to the market in 1902 under the name "Anästhesin".


Mechanism of action


Benzocaine acts to inhibit the voltage-dependent sodium channels (VDSCs) on the neuron membrane, stopping the propagation of the action potential.


Uses


Benzocaine is indicated to treat a variety of pain-related conditions. It may be used for:

  • Local anesthesia of oral and pharyngeal mucous membranes (sore throat, cold sores, mouth ulcers, toothache, sore gums, denture irritation)
  • Otic Pain (earache)
  • Surgical or procedural local anesthesia

Other uses


Benzocaine is used as a key ingredient in numerous pharmaceuticals:

  • Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear.
  • Some previous diet products such as Ayds.
  • Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer (in a continuous act) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted.
  • Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.
  • In Poland it is included, together with menthol and zinc oxide, in the liquid powder (not to be confused with the liquid face powder) used mainly after mosquito stings. Today's ready made Pudroderm was once used there as pharmaceutical compound.
  • Benzocaine is commonly found, particularly in Britain, as an impurity in street cocaine and also as a bulking agent in "legal highs".Whilst giving a numbing effect similar to cocaine on users' gums it does not actually produce the effects of cocaine. Also benzocaine can and has been mistaken for a false positive for cocaine.
  • Benzocaine was used in synthesis of Leteprinim.

Experimental Properties


PropertyValueSource
melting point92 °CPhysProp
boiling point310 °CPhysProp
water solubility1310 mg/L (at 30 °C)YALKOWSKY,SH & HE,Y (2003)
logP1.86HANSCH,C ET AL. (1995)
pKa2.51 (at 25 °C)PERRIN,DD (1965)

Predicted Properties


PropertyValueSource
Water Solubility2.85 mg/mLALOGPS
logP2.2ALOGPS
logP1.5ChemAxon
logS-1.8ALOGPS
pKa (Strongest Basic)2.78ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area52.32 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity47.53 m3·mol-1ChemAxon
Polarizability17.46 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon


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